Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.
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چکیده
منابع مشابه
Gold levels produced by treatment with auranofin and sodium aurothiomalate.
Sixty-three patients with rheumatoid arthritis were randomly divided into 3 groups, and treated with either sodium aurothiomalate (Myocrisin), auranofin, or placebo. Gold levels in whole blood, plasma, and haemolysate were measured serially along with clinical and laboratory parameters of efficacy. Auranofin produced a higher ratio of haemolysate to plasma gold than Myocrisin, and it appears th...
متن کاملGold nephropathy.
The early use of gold in medicine and dentistry dates back to the ancient Chinese and Egyptians. The discovery in 1890 that gold salts were toxic in vitro to tubercle bacilli led to the extensive treatment of tuberculosis with gold salts in the first three decades of this century. Eventually, gold therapy was extended to arthritis and lupus erythematosus, because of the belief that these diseas...
متن کاملLatent human leukocyte collagenase can be activated by gold thioglucose and gold sodium thiomalate, but not by auranofin.
Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercurial activators.
متن کاملAuranofin. New oral gold compound for treatment of rheumatoid arthritis.
Eight patients with rheumatoid arthritis were treated with SK & F D-39162 (auranofin), a new oral gold compound which was effective in suppressing adjuvant-induced arthritis in rats. Clinical and humoral parameters were studied during a 3-month period of drug administration followed by a 3-month period under placebo. The drug was absorbed, well tolerated, and its action was manifested by a drop...
متن کاملFormation of a cationic gold(I) complex and disulfide by oxidation of the antiarthritic gold drug auranofin.
The mechanism of action of auranofin, an antiarthritic gold(I) drug, is unknown, but several studies suggest that oxidation may be important for its biochemical effect. Bulk electrolysis studies on auranofin [(Et(3)P)Au(TATG); TATG = 2,3,4,6-tetraacetyl-1-thio-d-glucopyranosato] at +1.2 and +1.6 V versus Ag/AgCl in 0.1 M Bu(4)NBF(4)/CH(2)Cl(2) results in n values of 0.5 and >2 electrons, respec...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1984
ISSN: 0003-4967
DOI: 10.1136/ard.43.3.511